Tumor cells cotransfected with interleukin-7 and B7.1 genes induce CD25 and CD28 on tumor-infiltrating T lymphocytes and are strong vaccines

Vaccination of tumor cells transfected w

Vaccination of tumor cells transfected with the B7-1 (CD80) gene induces the anti-metastatic effect and tumor immunity in mice

✍ Hideki Fujii; Manabu Inobe; Fuminari Kimura; Jun Murata; Masaaki Murakami; Yasuh 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 766 KB

The present study demonstrates that the transfection of B7-I or its variant MB7-2 genes into MHC class I+ tumor cells (B 16-BL6 or K I 735-M2 melanoma) resulted in the remarkable reduction of lung metastasis caused by i.v. injection into immunocompetent syngeneic mice. However, i.v. injection of the