✦ LIBER ✦

Tumor cell-enhanced sensitivity of vascular endothelial cells to photodynamic therapy

✍ Scribed by Zhengang Yang; Xiaochen Lu; Donita L. Frazier; Masoud Panjehpour; Dr. Mike A. Breider

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 834 KB
Volume: 15
Category: Article
ISSN: 0196-8092
DOI: 10.1002/lsm.1900150403

No coin nor oath required. For personal study only.

✦ Synopsis

Effective antitumor photodynamic therapy (PDT) may be related to damage of vasculature within the tumor. The purpose of this study was to determine if tumor cells secrete factors that stimulate proliferation of human umbilical vein endothelial cells (HU-VEC) and result in enhanced sensitivity of HUVEC to aluminumsulfonated phthalocyanine (A1SPc)-PDT. Three human tumor cell lines-pharyngeal squamous carcinoma, colonic carcinoma, and mammary carcinoma-were used in this study. Co-culture of HUVEC and either squamous carcinoma or colonic carcinoma, but not mammary carcinoma, significantly increased HUVEC proliferation and AlSPc-PDT mediated cell damage. In addition, supernatant from squamous carcinoma and colonic carcinoma cultures also stimulated HUVEC proliferation and sensitivity to AlSPc-PDT. Both supernatant and cell lysate from squamous carcinoma cells contained angiogenic factors consistent with basic and acidic fibroblast growth factors, as evidenced by Western blot analysis and BALB/c 3T3 fibroblast cell proliferation assays. Collectively, these results suggest that selected tumor cell lines produce angiogenic factors that induce HUVEC proliferation and subsequently enhance sensitivity to AlSPc-PDT.

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