## Abstract ## BACKGROUND The goal of the current study was to investigate the prognostic impact of proliferative activity, together with the other classic clinicopathologic prognostic factors (tumor size, tumor grade, receptor status, ploidy, and lymph node status), in breast carcinoma by countin
Tumor angiogenesis is an independent prognostic indicator in primary breast carcinoma
β Scribed by Masakazu Toi; Takeshi Tominaga; Jitsuo Kashitani
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- French
- Weight
- 422 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
β¦ Synopsis
Jitsuo KASHITANI~ and Takeshi TOMINAGA~
Clinical importance of tumor angiogenesis, especially its significance as a prognostic indicator, was examined in 125 primary breast-cancer patients. The grade of neovascularization was assessed by the vessel density which was obtained by immunocytochemical staining for factor Vlll antigen. Post-
π SIMILAR VOLUMES
were used as a control group. p53 overexpression indicating a mutated p53 gene was analyzed by immunohistochemistry using the mouse monoclonal antibody D0-7. ## RESULTS. Approximately 82% of carcinomas that recurred locally expressed p53 compared with only 29% of those with local control (P Γ΅ 0.0
Background. Tumor angiogenesis has been shown to correlate with tumor size, metastatic potential, and prognosis in breast and other cancers. Studies in head and neck cancer have suggested a similar correlation, but results have been inconclusive. This study was performed to determine the correlation