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Is p53 an independent prognostic factor in patients with laryngeal carcinoma?

✍ Scribed by Ashwatha Narayana; Andrew T. M. Vaughan; Saroo Gunaratne; Satinder Kathuria; Scott A. Walter; Sarada P. Reddy

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 472 KB
Volume: 82
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19980115)82:2<286::aid-cncr7>3.0.co;2-p

No coin nor oath required. For personal study only.

✦ Synopsis

were used as a control group. p53 overexpression indicating a mutated p53 gene was analyzed by immunohistochemistry using the mouse monoclonal antibody D0-7.

RESULTS.

Approximately 82% of carcinomas that recurred locally expressed p53 compared with only 29% of those with local control (P õ 0.001). No significant relation was noted between p53 expression and histologic grade. Intensity of staining did not predict tumor recurrence.

CONCLUSIONS.

The authors believe that this case-controlled study demonstrated the role of p53 as an independent prognostic factor in patients with early stage glottic carcinoma.

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