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Tumor-activated Prodrugs—A New Approach to Cancer Therapy

✍ Scribed by Denny, William A.

Book ID: 118010319
Publisher: Informa plc
Year: 2004
Tongue: English
Weight: 655 KB
Volume: 22
Category: Article
ISSN: 0735-7907
DOI: 10.1081/cnv-200027148

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Inactivation of the tumour suppressors p53 and p16 INK4a or activating mutations in the ras oncogene are the most common genetic alterations found in human cancers. In this review, novel approaches designed to evaluate the effect of targeting intracellular molecules are described and it is shown how