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Tubular toxicity of cyclosporine A and the influence of endothelin-1 in renal cell culture models (LLC-PK1and MDCK)

✍ Scribed by Lothar Bernd Zimmerhackl; Hector Mesa; Frank Krämer; Christina Kölmel; Gerd Wiegele; Matthias Brandis

Publisher
Springer
Year
1997
Tongue
English
Weight
260 KB
Volume
11
Category
Article
ISSN
0931-041X

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Effects of lipoproteins on cyclosporine a toxicity and uptake in LLC-PK1 pig kidney cells
✍ Kathy D. Peteherych; Kishor M. Wasan 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 179 KB

Cyclosporine A (CSA) is an effective immunosuppressant, but side effects such as renal toxicity can limit its therapeutic use. The current studies investigate the effects of lipoproteins on CSA-induced renal toxicity in the pig epithelial cell line LLC-PK 1 . Protein synthesis and tritiated CSA were