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Tuberous sclerosis causing mutants of the TSC2 gene product affect proliferation and p27 expression

✍ Scribed by Soucek, Thomas; Rosner, Margit; Miloloza, Angelina; Kubista, Marion; Cheadle, Jeremy P; Sampson, Julian R; Hengstschläger, Markus

Book ID
110065882
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
197 KB
Volume
20
Category
Article
ISSN
0950-9232

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## Abstract We investigated the effects of overexpression of the tuberous sclerosis‐1 and ‐2 (__TSC1/2__) gene products (hamartin and tuberin, respectively) in the human kidney epithelial cell line 293 with an inducible expression system. As we had observed previously in fibroblasts, 293 cells over