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Tu1916 Berberine Potently Activates AMPK and Inhibits mTORC1, ERK and Cell Cycle Progression of Human Pancreatic Cancer Cells In Vitro and Reduces the Growth of Human Pancreatic Cancer Xenografts In Vivo

✍ Scribed by Ming, Ming; Wang, Jia; Sinnett-Smith, James; Young, Steven H.; Rozengurt, Enrique

Book ID
123245519
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
65 KB
Volume
146
Category
Article
ISSN
0016-5085

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## Abstract Berberine has been shown to have anti‐carcinogenic effects. Since p53 is the most commonly mutated tumor suppressor gene, and a lack of functional p53 is associated with an increased risk of cancer development, we examined the effects of berberine on p53‐positive and p53‐deficient non‐s