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Tu1889 The Isoquinoline Alkaloid Berberine Inhibits the Growth of Human Pancreatic Cancer Cells In Vitro and In Vivo

✍ Scribed by Sinnett-Smith, James; Kisfalvi, Krisztina; Young, Steven H.; Hines, Oscar J.; Eibl, Guido; Rozengurt, Enrique

Book ID: 122774557
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 52 KB
Volume: 144
Category: Article
ISSN: 0016-5085
DOI: 10.1016/S0016-5085(13)63246-1

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## Abstract Berberine has been shown to have anti‐carcinogenic effects. Since p53 is the most commonly mutated tumor suppressor gene, and a lack of functional p53 is associated with an increased risk of cancer development, we examined the effects of berberine on p53‐positive and p53‐deficient non‐s