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TSC1-2 tumour suppressor and regulation of mTOR signalling: linking cell growth and proliferation?

✍ Scribed by Greg M Findlay; Laura S Harrington; Richard F Lamb


Book ID
116504943
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
155 KB
Volume
15
Category
Article
ISSN
0959-437X

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RNAi has been useful in the study of biochemical pathways, but has not been widely used as a tool in metabolic engineering. The work described here makes use of double-stranded RNA (dsRNA) for the post-transcriptional gene silencing of TSC1 in Drosophila S2 cells. TSC1 downregulates the insulin-medi