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Tryptophan and inhibitors of tryptophan 2,3-dioxygenase as antidepressants

โœ Scribed by Young, S. N.


Book ID
126905765
Publisher
SAGE Publications
Year
2014
Tongue
English
Weight
717 KB
Volume
28
Category
Article
ISSN
0269-8811

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## Abstract The first and rateโ€limiting step of the kynurenine pathway, in which tryptophan (Trp) is converted to __N__โ€formylkynurenine is catalyzed by two hemeโ€containing proteins, Indoleamine 2,3โ€dioxygenase (IDO), and Tryptophan 2,3โ€dioxygenase (TDO). In mammals, TDO is found exclusively in liv