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Truncations of the C-Terminus Have Different Effects on the Conformation and Activity of Phosphatidylinositol Transfer Protein †

✍ Scribed by Voziyan, Paul A.; Tremblay, Jacqueline M.; Yarbrough, Lynwood R.; Helmkamp, George M.

Book ID
127002284
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
303 KB
Volume
35
Category
Article
ISSN
0006-2960

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## Abstract The β‐amyloid protein (Aβ) is derived by proteolytic processing of the amyloid protein precursor (APP). Cleavage of APP by β‐secretase generates a C‐terminal fragment (APP‐CTFβ), which is subsequently cleaved by γ‐secretase to produce Aβ. Our previous studies have shown that the proteas