Truncation of the C-terminus of human MLH1 blocks intracellular stabilization of PMS2 and disrupts DNA mismatch repair
β Scribed by Azizah B. Mohd; Brett Palama; Scott E. Nelson; Guy Tomer; Megan Nguyen; Xin Huo; Andrew B. Buermeyer
- Book ID
- 118435556
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 674 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1568-7864
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## Abstract DNA mismatch repair (MMR) is one of the several enzyme systems involved in DNA homeostasis. DNA MMR is involved in the repair of specific types of errors that occur during new DNA synthesis; loss of this system leads to an accelerated accumulation of potential mutations, and predisposes