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Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer

✍ Scribed by Versteege, Isabella; Sévenet, Nicolas; Lange, Julian; Rousseau-Merck, Marie-Françoise; Ambros, Peter; Handgretinger, Rupert; Aurias, Alain; Delattre, Olivier


Book ID
109716587
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
298 KB
Volume
394
Category
Article
ISSN
0028-0836

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The hSNF5/INI1 gene on chromosome 22 has been implicated as a tumor suppressor gene in pediatric rhabdoid tumor, an aggressive malignancy that generally occurs in the first two years of life. The most common sites for tumor development are the brain and kidney. We and other investigators have identi