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Targeting cyclin D1, a downstream effector of INI1/hSNF5, in rhabdoid tumors

✍ Scribed by Kalpana, G V; Alarcon-Vargas, D; Zhang, Z; Agarwal, B; Challagulla, K; Mani, S

Book ID
110070146
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
398 KB
Volume
25
Category
Article
ISSN
0950-9232

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The hSNF5/INI1 gene on chromosome 22 has been implicated as a tumor suppressor gene in pediatric rhabdoid tumor, an aggressive malignancy that generally occurs in the first two years of life. The most common sites for tumor development are the brain and kidney. We and other investigators have identi

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Aberrations of the hSNF5/INI1 gene are restricted to malignant rhabdoid tumors or atypical teratoid/rhabdoid tumors in pediatric solid tumors
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## Abstract The __hSNF5/INI1__ gene, which encodes a subunit of the SWI/SNF family of chromatin‐remodeling complexes and is located at 22q11.2, has been reported as a tumor suppressor gene inactivated in malignant rhabdoid tumors (MRTs). We analyzed this gene in varieties of pediatric solid tumors