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Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells

✍ Scribed by Rose, Christine R.; Blum, Robert; Pichler, Bruno; Lepier, Alexandra; Kafitz, Karl W.; Konnerth, Arthur


Book ID
109891402
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
511 KB
Volume
426
Category
Article
ISSN
0028-0836

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Truncated TrkB mediates the endocytosis
✍ Ralph F Alderson; Rory Curtis; Andrea L Alterman; Ronald M Lindsay; Peter S DiSt πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 English βš– 977 KB

Binding and cross-linking studies with radiolabeled neurotrophins demonstrate that cultured rat hippocampal astrocytes lack full-length TrkB, but do express high levels of truncated TrkB (tTrkB). In astrocytes and Schwann cells, tTrkB appears to have the novel function of mediating the endocytosis o