Trophoblast cell lineage in cloned mouse embryos
β Scribed by Mayumi Oda; Kunio Shiota; Satoshi Tanaka
- Book ID
- 108944215
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 333 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0012-1592
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Diploid mouse embryos containing only maternal DNA (parthenotes) fail, in part, because the inner cell mass does not induce the trophoblast to grow. In this study, we asked whether any of the defects in parthenotes may arise from alterations in trophoblast function. We examined the expression of gen
## Abstract The developmental potential of the inner cell mass (ICM) of the cultured mouse embryo was determined by testing the ability of the ICM to regenerate trophoblast in vitro. ICM's isolated by immunosurgery from either single or chimeric embryos were able to regenerate trophoblast when they