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TrkA NGF receptor plays a role in the modulation of p75NTR expression

✍ Scribed by Sherri L. Rankin; Clifford S. Guy; Karen M. Mearow


Book ID
116767781
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
234 KB
Volume
383
Category
Article
ISSN
0304-3940

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Nerve growth factor (NGF) has been demonstrated to support survival and differentiation of neuronal cells. Recently, a role of NGF in neuronal apoptosis has been suggested. NGF binds to tropomyosin receptor kinase A (TrkA) and to 75-kDa NGF receptor (p75 NTR ). TrkA is responsible for differentiatio