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Tritium labeling of the local anesthetic tetracaine via a polyhalogenated precursor

✍ Scribed by J. A. Egan; C. N. Filer


Book ID
111559507
Publisher
Springer
Year
2003
Tongue
English
Weight
246 KB
Volume
258
Category
Article
ISSN
1588-2780

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Synthesis of tritium labelled ropivacain
✍ Lars Gawell πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 French βš– 290 KB πŸ‘ 1 views

A potential local anaesthetic, ropivacaine, is synthesized labelled with tritium. The label is introduced by reduction of a racemic tetrahydropyridine derivative with tritium gas. Resolution into the labelled enantiomers is accomplished by preferential crystallization with added carrier. 3H NMR.