Synthesis of tritium labelled ropivacain
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Lars Gawell
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Article
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1987
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John Wiley and Sons
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French
β 290 KB
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A potential local anaesthetic, ropivacaine, is synthesized labelled with tritium. The label is introduced by reduction of a racemic tetrahydropyridine derivative with tritium gas. Resolution into the labelled enantiomers is accomplished by preferential crystallization with added carrier. 3H NMR.