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Tritium-Labeled N1-[3-(1H-imidazol-4-yl)propyl]-N2-propionylguanidine ([3H]UR-PI294), a High-Affinity Histamine H3 and H4 Receptor Radioligand

✍ Scribed by Patrick Igel; David Schnell; Günther Bernhardt; Roland Seifert; Armin Buschauer

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
238 KB
Volume
4
Category
Article
ISSN
1860-7179

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Inside Cover: Tritium-Labeled N1-[3-(1H-
Inside Cover: Tritium-Labeled N1-[3-(1H-imidazol-4-yl)propyl]-N2-propionylguanidine ([3H]UR-PI294), a High-Affinity Histamine H3 and H4 Receptor Radioligand / NG-Acylated Aminothiazolylpropylguanidines as Potent and Selective Histamine H2 Receptor Agonists (ChemMedChem 2/2009)
✍ Patrick Igel; David Schnell; Günther Bernhardt; Roland Seifert; Armin Buschauer; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 393 KB 👁 1 views

## Abstract The inside cover picture shows the human histamine H~2~ receptor and the H~2~ and H~3~/H~4~ receptor‐selective ligands identified. Bioisosteric replacement of the imidazole ring of the __N__^G^‐acyl‐imidazolylpropylguanidine with 2‐aminothiazole yielded potent and selective H~2~ recepto

Synthesis of [3H]-labelled 4-[Ethyl[2,5,
Synthesis of [3H]-labelled 4-[Ethyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]-2,3-[3H]-butan-1-ol: a high affinity radioligand for the corticotropin-releasing hormone type 1 receptor
✍ Anne-Cécile Hiebel; John S. Partilla; Richard B. Rothman; Arthur E. Jacobson; Ke 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 117 KB

3 H]-Labelled 4- [ethyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]-2,3-[ 3 H]-butan-1-ol (3b) was prepared as a novel non-peptidic radiolabelled high affinity antagonist of the corticotropin-releasing hormone type 1 receptor (CRHR 1 ) that could be useful as a more