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Trisomy 2 and 20 in two hepatoblastomas

✍ Scribed by Shirley W. Soukup; Beatrice L. Lampkin

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 825 KB
Volume: 3
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870030310

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✦ Synopsis

Abstract

Cytogenetic analysis of two pediatric hepatoblastomas is presented, comparing results in primary tumor samples, nude mouse xenographs, and lung metastases in one case. Both tumors had trisomy 2 and 20 in the primary tumors, along with other structural abnormalities. In subsequent passages/metastases, both tumors showed structural changes in one chromosome 2, resulting in partial trisomy 2q, along with structural changes of other chromosomes. Partial trisomy 1 q was also common to both tumors in late stages. Results are compared to those of embryonal rhabdomyosarcoma, where trisomy 2 has also been noted.

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