Trisomy 12 and structural abnormalities of 13q14 occurring in the same clone in chronic lymphocytic leukaemia
β Scribed by S Mould; A. Gardiner; M. Corcoran; D. G. Oscier
- Book ID
- 114425061
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 157 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0007-1048
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π SIMILAR VOLUMES
Deletions and translocations of 13q14 are the most frequent structural chromosome abnormalities found in chronic lymphocytic leukaemia (CLL). We have identified 13q14 translocations in the blood of 30 of 450 (6.6%) CLL patients by conventional cytogenetics, using tetradecanoyl phorbol 12-myristate 1
We performed cytogenetic analyses of peripheral blood lymphocytes from 82 Midwestern B-cell chronic lymphocytic leukemia (B-CLL) patients. The cells were cultured with mitogens for 3 4 days. At least I 5 metaphase cells were analyzed in 79 (96%) cases. Fifty (63%) of the 79 patients had clonal chrom