Co-existence of t(6;13)(p21;q14.1) and trisomy 12 in chronic lymphocytic leukemia
✍ Scribed by Fábio Morato de Oliveira, Lorena Lobo de Figueiredo Pontes, Sarah Cristina Bassi, Leandro Felipe Figueiredo Dalmazzo, Roberto Passetto Falcão
- Book ID
- 113093722
- Publisher
- Springer US
- Year
- 2011
- Tongue
- English
- Weight
- 232 KB
- Volume
- 29
- Category
- Article
- ISSN
- 1357-0560
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We describe the prenatal diagnosis and fetal phenotype of partial trisomy 12 (p13.3-pter) and partial trisomy 21 (pter-q21) due to a 3:1 segregation with tertiary aneuploidy transmitted from a maternal reciprocal translocation 12;21. Genetic amniocentesis of a 39-year-old gravida 2, para 1 woman at
## Abstract B‐cell chronic lymphocytic leukemia (B‐CLL) samples were screened for alterations in multiple tumor suppressor genes (__p53__ (17p13), __p__16 INK^4^ (9p21), and disrupted in B‐cell malignancy (__DBM__) (13q14)) by using poly‐merase chain reaction‐based assays. Eleven percent (11 of 96)