Trisomies 21 and 18 in two sibs; another case
โ Scribed by Dushan Soudek; Bruce McCreary; Parvaneh Laraya
- Book ID
- 118538716
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- English
- Weight
- 86 KB
- Volume
- 87
- Category
- Article
- ISSN
- 1097-6833
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
W e recently began a cytogenetic and molecular study of nondisjunction in leukemic Down syndrome individuals to determine whether the mechanism by which the extra chromosome 21 originates predisposes the individual to leukemia. In the present report, we summarize our observations on I8 patients with
Three patients with mental retardation and multiple congenital abnormalities are described. Although their clinical appearance was not suggestive of Down's syndrome, chromosome studies showed a non-disjunctional trisomy 21 in two of the patients. The third case had an unsuspected XXY karyotype.