A rare occurrence of trisomy 18 and trisomy 21 in a dizygotic twin pregnancy
โ Scribed by Harold M. P. Pelikan; Emilia K. Bijlsma; Willem J. van Wijngaarden
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 165 KB
- Volume
- 276
- Category
- Article
- ISSN
- 0003-9128
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A family is presented in which there were three different chromosome abnormalities in the children although the parents were cytogenetically normal. The proband had the karyotype 46,XX, r(18) (p11q23), a phenotypically normal brother was 47,XY,+mar, and another brother was a typical case of Down's s
In a study of 70 cases of trisomy 18 and 450 matched controls in the second trimester we have measured the maternal serum levels of the analytes alpha feto protein (AFP), free -human chorionic gonadotrophin (hCG) and pregnancy associated plasma protein-A (PAPP-A). We have found the median multiple o