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Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo

✍ Scribed by Mara B. Antonoff; Rohit Chugh; Daniel Borja-Cacho; Vikas Dudeja; Kimberly A. Clawson; Steven J. Skube; Brent S. Sorenson; Daniel A. Saltzman; Selwyn M. Vickers; Ashok K. Saluja


Book ID
118501305
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
467 KB
Volume
146
Category
Article
ISSN
0039-6060

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## Abstract We have recently described MAZ51, an indolinone that blocks the ligand‐induced autophosphorylation of VEGFR‐3, a receptor tyrosine kinase that plays a central role in the regulation of lymphangiogenesis. Here we show that MAZ51 is able to block the proliferation of VEGFR‐3‐expressing hu