𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Triple quadrupole linear ion trap mass spectrometer for the analysis of small molecules and macromolecules

✍ Scribed by Gérard Hopfgartner; Emmanuel Varesio; Viviane Tschäppät; Chantal Grivet; Emmanuel Bourgogne; Luc Alexis Leuthold

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
233 KB
Volume
39
Category
Article
ISSN
1076-5174

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Recently, linear ion traps (LITs) have been combined with quadrupole (Q), time‐of‐flight (TOF) and Fourier transform ion cyclotron resonance (FT‐ICR) mass spectrometery (MS). LITs can be used either as ion accumulation devices or as commercially available, stand‐alone mass spectrometers with MS^n^ capabilities. The combination of triple quadrupole MS with LIT technology in the form of an instrument of configuration QqLIT, using axial ejection, is particularly interesting, because this instrument retains the classical triple quadrupole scan functions such as selected reaction monitoring (SRM), product ion (PI), neutral loss (NL) and precursor ion (PC) while also providing access to sensitive ion trap experiments. For small molecules, quantitative and qualitative analysis can be performed using the same instrument. In addition, for peptide analysis, the enhanced multiply charged (EMC) scan allows an increase in selectivity, while the time‐delayed fragmentation (TDF) scan provides additional structural information. Various methods of operating the hybrid instrument are described for the case of the commercial Q TRAP (AB/MDS Sciex) and applications to drug metabolism analysis, quantitative confirmatory analysis, peptides analysis and automated nanoelectrospray (ESI‐chip‐MS) analysis are discussed. Copyright © 2004 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Theoretical and numerical analysis of th
Theoretical and numerical analysis of the behavior of ions injected into a quadrupole ion trap mass spectrometer
✍ Kiyomi Yoshinari 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 239 KB 👁 2 views

A numerical simulation method has been developed for the analysis of trapping ions injected into an ion trap mass spectrometer. This method was applied to clarify the effects of the following parameters on trapping efficiencies: (1) initial phase of the radio frequency (RF) drive voltage, (2) ion in

Fragmentation study of imatinib and char
Fragmentation study of imatinib and characterization of new imatinib metabolites by liquid chromatography–triple-quadrupole and linear ion trap mass spectrometers
✍ Marc Marull; Bertrand Rochat 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 442 KB

## Abstract Imatinib (Gleevec) is an anticancer drug that inhibits specific protein kinases involved in cell proliferation. Whereas this drug is considered to have opened a new era, various mechanisms of resistance have been associated with imatinib relapse. Drug disposition in cancer cells includi

Rapid screening and characterization of
Rapid screening and characterization of drug metabolites using a multiple ion monitoring–dependent MS/MS acquisition method on a hybrid triple quadrupole-linear ion trap mass spectrometer
✍ Ming Yao; Li Ma; W. Griffith Humphreys; Mingshe Zhu 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 281 KB

## Abstract A novel LC/MS/MS method that uses multiple ion monitoring (MIM) as a survey scan to trigger the acquisition of enhanced product ions (EPI) on a hybrid quadrupole‐linear ion trap mass spectrometer (Q TRAP) was developed for drug metabolite identification. In the MIM experiment, multiple

Thin-layer chromatography/electrospray i
Thin-layer chromatography/electrospray ionization triple-quadrupole linear ion trap mass spectrometry system: analysis of rhodamine dyes separated on reversed-phase C8 plates
✍ Michael J. Ford; Vilmos Kertesz; Gary J. Van Berkel 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 456 KB

## Abstract The direct analysis of separated rhodamine dyes on reversed‐phase C~8~ thin‐layer chromatography plates using a surface sampling/electrospray emitter probe coupled with a triple‐quadrupole linear ion trap mass spectrometer is presented. This report represents continuing work to advance

A novel approach to perform metabolite s
A novel approach to perform metabolite screening during the quantitative LC–MS/MS analyses of in vitro metabolic stability samples using a hybrid triple-quadrupole linear ion trap mass spectrometer
✍ Wilson Z. Shou; Lisa Magis; Austin C. Li; Weng Naidong; Matthew S. Bryant 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 243 KB

## Abstract __In vitro__ metabolic stability experiments using microsomes or other liver preparations are important components in the discovery and lead‐optimization stages of compound selection in the pharmaceutical industry. Currently, liquid chromatography–tandem mass spectrometric (LC–MS/MS) su

Combined Ion/Molecule Reactions and Mult
Combined Ion/Molecule Reactions and Multi-stage Tandem Mass Spectrometric Techniques in an Ion Trap Mass Spectrometer for the Characterization of Conjugated Ethylenic Epoxides. 1—Protonating Agents
✍ Mayran Sharifi; Jacques Einhorn 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 253 KB 👁 2 views

The potential of the ion trap mass spectrometer to characterize isomeric long-chain conjugated mono-or diethylenic epoxides was investigated using the multi-stage tandem mass spectrometric (MS n ) facilities of the instrument. In the proposed approach, mass-selected reagent ions obtained from common