Triple-Helical Nucleic Acids

✍ Scribed by Valery N. Soyfer Ph.D., Vladimir N. Potaman Ph.D. (auth.)

Publisher: Springer-Verlag New York
Year: 1996
Tongue: English
Leaves: 372
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

The ability of DNA to exist in configurations other than its classical double-stranded form has been known for many years. There has been a spectacular recent surge of interest in these forms, notably in the three-stranded or triple-helical form. Triplex-like nucleic acids are now known to exist in vivo, and may well participate in significant biological processes. Interest in triple-helical nucleic acids has been greatly stimulated by their potential exploitation to control gene expression, serve as tools in genome mapping strategies, etc. The authors have written an encyclopedic introduction to nucleic acid triplexes based on many years of familiarity with the topic. The book includes information on chemistry, conformation, physical properties, applications, and hypotheses about the biological role of triplexes. It pays particular attention to the different methods for investigating these molecules, a feature which will be welcomed by those new to the field.

✦ Table of Contents

Front Matter....Pages i-xiv
The Discovery of Triple-Stranded Nucleic Acids....Pages 1-46
Methods of Triplex Study....Pages 47-99
General Features of Triplex Structures....Pages 100-150
Triplex Recognition....Pages 151-193
The Forces Participating in Triplex Stabilization....Pages 194-219
In Vivo Significance of Triple-Stranded Nucleic Acid Structures....Pages 220-252
Possible Spheres of Application of Intermolecular Triplexes....Pages 253-284
Back Matter....Pages 285-360

✦ Subjects

Biochemistry, general

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