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Triphenylphosphine promoted addition of dimethyl acetylenedicarboxylate to 1,2-benzoquinones: facile synthesis of novel γ-spirolactones

✍ Scribed by Nair, Vijay; Nair, J. Somarajan; Vinod, A. U.; Rath, Nigam P.


Book ID
119975054
Publisher
Royal Society of Chemistry
Year
1997
Weight
90 KB
Volume
21
Category
Article
ISSN
1472-7781

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The reaction of isoquinoline and dimethy
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The 1,4-dipolar intermediate generated by the addition of isoquinoline to dimethyl acetylenedicarboxylate is trapped by 1,2-and 1,4-benzoquinones to afford spiro[1,3]oxazino[2,3-a]isoquinoline derivatives in high yields.