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The reaction of isoquinoline and dimethyl acetylenedicarboxylate with 1,2- and 1,4-benzoquinones: a novel synthesis of spiro[1,3]oxazino[2,3-a]isoquinolines

✍ Scribed by Vijay Nair; A.R Sreekanth; A.T Biju; Nigam P Rath

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
221 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

The 1,4-dipolar intermediate generated by the addition of isoquinoline to dimethyl acetylenedicarboxylate is trapped by 1,2-and 1,4-benzoquinones to afford spiro[1,3]oxazino[2,3-a]isoquinoline derivatives in high yields.

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