Triphenylphosphine catalyzed formation of functionalized 2-aminothiophenes

✍ Scribed by David Virieux; Anne-Françoise Guillouzic; Henri-Jean Cristau

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 124 KB
• Volume: 18
• Category: Article
• ISSN: 1042-7163
• DOI: 10.1002/hc.20300

✦ Synopsis

Abstract

Triphenylphosphine was used as a nucleophilic catalyst in the addition–cyclization reaction of phenyl isothiocyanate with electron‐deficient allenes. This strategy offers a new approach for the synthesis of 2‐aminothiophenes under neutral conditions. © 2007 Wiley Periodicals, Inc. Heteroatom Chem 18:312–315, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20300