TRINUCLEOTIDE-REPEAT EXPANSIONS AND NEURODEGENERATIVE DISEASE: A MECHANISM OF PATHOGENESIS
β Scribed by Anthony J. Hannan
- Book ID
- 108936835
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 690 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0305-1870
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The Huntington's disease gene contains an expanded unstable (CAG), repeat, and the repeat lengths have been shown to correlate with the age of onset. Using detailed clinical scales, we evaluated the rate of progression of Huntington's disease and its relationship to the number of triplet repeats. We
Huntington disease (HD) is an autosomal dominant neurodegenerative disorder associated with expansions of an unstable CAG trinucleotide repeat in exon 1 of the IT15 gene. In normal individuals, IT15 contains up to 35 CAG repeats, while in affected the repeat length is >36. Polymerase chain reaction