𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Unstable expansion of triplet repeats as a new disease mechanism for neurodegenerative diseases

✍ Scribed by Shoji Tsuji


Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
780 KB
Volume
41
Category
Article
ISSN
1435-232X

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


A novel PCR-based approach for the detec
✍ Ioannis Panagopoulos; Carin Lassen; Ulf Kristoffersson; Pierre Γ…man πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 332 KB πŸ‘ 2 views

Huntington disease (HD) is an autosomal dominant neurodegenerative disorder associated with expansions of an unstable CAG trinucleotide repeat in exon 1 of the IT15 gene. In normal individuals, IT15 contains up to 35 CAG repeats, while in affected the repeat length is >36. Polymerase chain reaction

Polyglutamine-induced ion channels: a po
✍ Yutaka Hirakura; Rustam Azimov; Rushania Azimova; Bruce L. Kagan πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 129 KB πŸ‘ 1 views

CAG repeats resulting in long polyglutamine tracts have been implicated in the pathogenesis of at least eight neurodegenerative diseases including Huntington. Expression of polyglutamine repeats is required for disease and increasing length of the repeats leads to earlier onset of illness (anticipat