Triiodothyronine (T3) increases cisplatin nephrotoxicity in young and adult rats

✍ Scribed by Dorothea Appenroth; Stephan Gambaryan; Vera Bakhteeva; Klaus Winnefeld; Heinz Schröter; Steffen Gerhardt; Helmut Bräunlich

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 368 KB
• Volume: 10
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/jat.2550100603

✦ Synopsis

Abstract

The influence of pretreatment with triiodothyronine (T~3~) on cisplatin (CP)‐induced nephrotoxicity was investigated in 10‐ and 55‐day‐old rats. Triiodothyronine pretreatment enhanced CP proteinuria in young and adult rats, and increased blood urea nitrogen concentration in 55‐day‐old rats. As T~3~ decreased Pt concentrations in renal tisssue, the enhanced nephrotoxicity of CP by T~3~ must have another mechanism. Enhanced CP nephrotoxicity is discussed in connection with an increase of glutathione concentration obtained in renal tissue as a consequence of T~3~ pretreatment.