The nephrotoxic potentials of cisplatin and carboplatin, alone and in combination with the aminoglycoside antibiotic tobramycin, were compared in male rats. Sixty (60) male Sprague-Dawley rats were divided into six groups of ten rats each and received the following treatments: Group I, saline; group
โฆ LIBER โฆ
Potentiated nephrotoxicity of cisplatin when combined with amikacin comparing young and adult rats
โ Scribed by Hermina T. M. Jongejan; Abraham P. Provoost; Jan C. Molenaar
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 485 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0931-041X
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We have compared the therapeutic efficacy as well as the kinetics of treatment-induced apoptosis and necrosis of the maximum tolerated dose (MTD) of doxorubicin (DOX) or cisplatin (CDDP) combined with long-duration, low-temperature whole-body hyperthermia (LL-WBH, at 40.0ยฐC for 6 hr), with the combi