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Triggering of the lethal hit in human cytotoxic T lymphocytes: a functional role for a 103-kDa T cell- specific activation antigen

✍ Scribed by Bernhard Fleischer; Dolores J. Schendel; Dierk Von Steldern

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 624 KB
Volume: 16
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830160705

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✦ Synopsis

A monoclonal antibody (CB.l) is described that defines a new triggering signal for human cytotoxic T lymphocytes (CTL). The antibody precipitates a 103-kDa surface antigen from activated normal human T cells. The antigen is undetectable or present in only low amounts on resting T lymphocytes but its expression increases strongly after activation and proliferation on T4' and T8' T lymphocytes. Binding of antibody CB.l to CTL results in triggering of the lethal hit. This induction of cytotoxicity is dependent on cross-linking of CTL and an Fc receptor-bearing target cell with CB. 1 and requires Ca2+ like antigen-specific triggering. CB. l-induced triggering can be specifically inhibited by binding of antibodies to the T8 or T4 molecules on T8' or T4+ CTL.

* Supported by the Deutsche Forschungsgemeinschaft (SFB 112).

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