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Tricyclic heteroaromatic systems: [1]Benzopyrano-pyrazol-4-ones as benzodiazepine receptor ligands

✍ Scribed by Vittoria Colotta; Lucia Cecchi; Fabrizio Melani; Guido Filacchioni; Claudia Martini; Sabrina Gelli; Antonio Lucacchini

Book ID: 102408172
Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 466 KB
Volume: 80
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600800317

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✦ Synopsis

The synthesis of a series of 8-substituted 1,4-dihydro-1-aryl-3-methyl-[1]benzopyrano[3,4-d]pyrazol-4-ones (series 7) 2,4-dihydro-2-aryl-3-methyl[1]benzopyrano[4,3-c]pyrazol-4-ones (series 8) is reported. Compounds of series 7 and 8 were tested for their ability to displace [3H]flunitrazepam from bovine brain membranes and for their in vitro biological activity. The results allowed some conclusions to be drawn about the structural requirements of the benzodiazepine recognition site within this class of unusual ligands.

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