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Tricyclic Farnesyl Protein Transferase Inhibitors: Crystallographic and Calorimetric Studies of Structure−Activity Relationships †

✍ Scribed by Strickland, Corey L.; Weber, Patricia C.; Windsor, William T.; Wu, Zhen; Le, Hung V.; Albanese, Margaret M.; Alvarez, Carmen S.; Cesarz, David; del Rosario, Joycelyn; Deskus, Jeffrey; Mallams, Alan K.; Njoroge, F. George; Piwinski, John J.; Remiszewski, Stacy; Rossman, Randall R.; Taveras, Arthur G.; Vibulbhan, Bancha; Doll, Ronald J.; Girijavallabhan, Viyyoor M.; Ganguly, Ashit K.


Book ID
124058993
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
255 KB
Volume
42
Category
Article
ISSN
0022-2623

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ChemInform Abstract: Novel Tricyclic Ami
✍ F. G. NJOROGE; B. VIBULBHAN; C. S. ALVAREZ; W. R. BISHOP; J. PETRIN; R. J. DOLL; 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 2 views

Novel Tricyclic Aminoacetyl and Sulfonamide Inhibitors of RAS Farnesyl Protein Transferase. -It is shown that derivatization of the amino group with a phthaloyl moiety increases inhibitory activity of the title compounds, cf. (IIIc) and (IIId). The potent inhibitors (III) and (V) are non-peptidic,