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Tricyclic analogues of artemisinin: synthesis and antimalarial activity of (+)-4,5-secoartemisinin and (?)-5-nor-4,5-secoartemisinin

✍ Scribed by Avery, Mitchell A.; Chong, Wesley K. M.; Bupp, James E.


Book ID
120590277
Publisher
The Royal Society of Chemistry
Year
1990
Tongue
English
Weight
299 KB
Volume
21
Category
Article
ISSN
0022-4936

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Two sets of tricyclic 1,2,4-trioxanes containing the ABC (10, 11) and ACD ring portions (21, 22, 32, 33, 37, and 38) of artemisinin (1) were synthesized by successive photo-oxygenation of appropriate enol-ether precursors to 1,2-dioxanes and inter-and intramolecular reaction with a carbonyl compound