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Trichloroethyl carbonate I. Synthesis, physical properties, and pharmacology

✍ Scribed by H. C. Caldwell; H. J. Adams; Donald E. Rivard; Joseph V. Swintosky

Publisher: John Wiley and Sons
Year: 1967
Tongue: English
Weight: 225 KB
Volume: 56
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600560734

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✦ Synopsis

Trichloroethyl carbonate was prepared from trichloroethanol and phosgene. It is a tasteless, crystalline solid with limited solubility in water. Pharmacological comparisons of trichloroethyl carbonate and trichloroethanol reveal that these compounds are about equitoxic and equipotent in decreasing spontaneous motor activity in mice after oral administration. These observations suggest that this carbonate is a prodrug of trichloroethanol.

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## Abstract For Abstract see ChemInform Abstract in Full Text.