Tributyltin exposure causes decreased granzyme B and perforin levels in human natural killer cells
β Scribed by LeeShawn D Thomas; Hemangini Shah; Stephanie A Green; Arthur D Bankhurst; Margaret M Whalen
- Book ID
- 108287113
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 303 KB
- Volume
- 200
- Category
- Article
- ISSN
- 0300-483X
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## Abstract The purpose of this study was to investigate the role that tributyltin (TBT)βinduced decreases in ATP levels may play in TBTβinduced decreases in the tumor lysing (lytic) function of natural killer (NK) cells. NK cells are a subset of lymphocytes that act as an initial immune defense ag
## Abstract Destruction of tumor cells is a key function of natural killer (NK) cells. Previous studies have shown that tributyltin (TBT) can significantly reduce the lytic function of the human NK cells with accompanying increases in the phosphorylation (activation) states of the mitogen activated