NK cells are lymphocytes in the non-adaptive immune system that protect the body against intracellular pathogens and eliminate tumor cells. Tributyltin (TBT) is a toxic chemical that has been detected in human foods as well as in human blood. The role of TBT in immunosuppression has been described,
Effects of interleukins 2 and 12 on the levels of granzyme B and perforin and their mRNAs in tributyltin-exposed human natural killer cells
β Scribed by LeeShawn D. Thomas; Hemangini Shah; Arthur D. Bankhurst; Margaret M. Whalen
- Publisher
- Springer-Verlag
- Year
- 2005
- Tongue
- English
- Weight
- 365 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0340-5761
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## Abstract Destruction of tumor cells is a key function of natural killer (NK) cells. Previous studies have shown that tributyltin (TBT) can significantly reduce the lytic function of the human NK cells with accompanying increases in the phosphorylation (activation) states of the mitogen activated
The possible effect of IL-2, a,P-IFN and poly I:C (an IFN inducer) administration on the generation of NK cells of LI and BM-reconstituted animals was investigated. B6D2FI mice were LI (9.5 Gy) by total-body irradiation and reconstituted by i.v. injection of different doses (ranging from lo6 to 2 x