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TRH-degrading Enzymes in Rat-Insulinoma Cell Line RINm 5F

✍ Scribed by P. SALERS; L'H. OUAFIK; P. GIRAUD; A. DUTOUR; J. Y. MALTESE; C. OLIVER

Book ID
119863796
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
115 KB
Volume
553
Category
Article
ISSN
0890-6564

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πŸ“œ SIMILAR VOLUMES

Evidence for pyroglutamyl peptidase I an
Evidence for pyroglutamyl peptidase I and prolyl endopeptidase activities in the rat insulinoma cell line RINm 5F: lack of relationship with TRH metabolism
✍ Paul Salers; L'Houcine Ouafik; Pierre Giraud; Anne Dutour; Jean-Yves Maltese; Ch πŸ“‚ Article πŸ“… 1991 πŸ› Springer 🌐 English βš– 805 KB

Thyrotropin-Releasing hormone (TRH)-degrading pyroglutamyl peptidase I (PGP I) and prolylendopeptidase (PE) activities have been demonstrated in rat insulinoma RINm 5F cell line. These two enzymes catalyze the conversion of TRH to Histydyl-Proline-Diketopiperazine and to acid TRH respectively. After

Inhibition of insulin production by cypr
Inhibition of insulin production by cyproheptadine in RINm5F rat insulinoma cells
✍ Miller, C. P. ;Reape, T. J. ;Fischer, L. J. πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 733 KB

## ABSTRACE The clonal insulin producing cell line RINm5F was evaluated as a model for the action of cyproheptadine (CPH)-like diabetogenic compounds in the rat pancreas. Treatment with 10 & l CPH and selected structural analogs under culture conditions produced a progressive loss of cellular insu