Specificity of receptors for GIP and GLP-1 in RINm5F rat insulinoma cells
✍ Scribed by B Gallwitz; WE Schmidt; M Witt; UR Fölsch I.
- Book ID
- 118399367
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 87 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0167-0115
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## ABSTRACE The clonal insulin producing cell line RINm5F was evaluated as a model for the action of cyproheptadine (CPH)-like diabetogenic compounds in the rat pancreas. Treatment with 10 & l CPH and selected structural analogs under culture conditions produced a progressive loss of cellular insu
Thyrotropin-Releasing hormone (TRH)-degrading pyroglutamyl peptidase I (PGP I) and prolylendopeptidase (PE) activities have been demonstrated in rat insulinoma RINm 5F cell line. These two enzymes catalyze the conversion of TRH to Histydyl-Proline-Diketopiperazine and to acid TRH respectively. After