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TRF2 inhibition promotes anchorage-independent growth of telomerase-positive human fibroblasts

✍ Scribed by Brunori, M; Mathieu, N; Ricoul, M; Bauwens, S; Koering, C E; Roborel de Climens, A; Belleville, A; Wang, Q; Puisieux, I; Décimo, D

Book ID
110070168
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
248 KB
Volume
25
Category
Article
ISSN
0950-9232

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Anchorage-independent growth, i.e., growth in semi-solid medium is considered a marker of cellular transformation of fibroblast cells. Diploid human fibroblasts ordinarily do not exhibit such growth but can grow transiently when medium contains high concentrations of fetal bovine serum. This suggest