Reaction of the imine derived from L-tryptophan methyl ester and senecialdehyde with Fmoe-L-Pro-Cl induces an acyliminium Pictet-Spengler condensation, yielding a mixture of cis and trans tetrahydro-13-carbolines. Deprotection of the cis product with concomitant diketopiperazine formation afforded t
Tremorgenic mycotoxins: synthesis of 6-demethoxyfumitremorgin C
β Scribed by Gerard J. O'Malley; Michael P. Cava
- Book ID
- 108382710
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 197 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
Concise Synthesis of the Cell Cycle Inhibitor Demethoxyfumitremorgin C. -The imine (III) reacts with the proline derivative (IV) via an acyliminium Pictet-Spengler condensation to give the tetrahydro-Ξ²-carbolines (V) and (VI), thus providing a rapid access to the title compound (VII) and its epimer
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