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Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates

โœ Scribed by Kirk, Allan D.; Burkly, Linda C.; Batty, D. Scott; Baumgartner, Roxanne E.; Berning, Justin D.; Buchanan, Kelvin; Fechner, John H.; Germond, Rhonda L.; Kampen, Robert L.; Patterson, Noelle B.; Swanson, S. John; Tadaki, Douglas K.; TenHoor, Christopher N.; White, Leonard; Knechtle, Stuart J.; Harlan, David M.


Book ID
109832167
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
688 KB
Volume
5
Category
Article
ISSN
1078-8956

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Treatment with humanized monoclonal anti
โœ Kirk, Allan D.; Burkly, Linda C.; Batty, D. Scott; Baumgartner, Roxanne E.; Bern ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Nature Publishing Group ๐ŸŒ English โš– 688 KB

CD154 is the ligand for the receptor CD40. This ligand-receptor pair mediates endothelial and antigen-presenting cell activation, and facilitates the interaction of these cells with T cells and platelets. We demonstrate here that administration of a CD154-specific monoclonal antibody (hu5C8) allows