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Effects of Combined Treatment with CD25- and CD154-Specific Monoclonal Antibodies in Non-Human Primate Allotransplantation

✍ Scribed by He Xu; Eric A. Elster; Patrick J. Blair; Linda C. Burkly; Douglas K. Tadaki; David M. Harlan; Allan D. Kirk


Book ID
114440655
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
83 KB
Volume
3
Category
Article
ISSN
1600-6135

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Treatment with humanized monoclonal anti
✍ Kirk, Allan D.; Burkly, Linda C.; Batty, D. Scott; Baumgartner, Roxanne E.; Bern πŸ“‚ Article πŸ“… 1999 πŸ› Nature Publishing Group 🌐 English βš– 688 KB

CD154 is the ligand for the receptor CD40. This ligand-receptor pair mediates endothelial and antigen-presenting cell activation, and facilitates the interaction of these cells with T cells and platelets. We demonstrate here that administration of a CD154-specific monoclonal antibody (hu5C8) allows