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Treatment of the rat R-1 rhabdomyosarcoma with methotrexate and radiation; effects of timing on cell survival and tumour growth delay

✍ Scribed by J. B. A. Kipp; H. B. Kal; A. H. van Gennip; A. H. van Berkel


Book ID
112578237
Publisher
Springer-Verlag
Year
1993
Tongue
English
Weight
610 KB
Volume
119
Category
Article
ISSN
1432-1335

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Pharmacokinetics and biological response
✍ J. B. A. Kipp; A. Leyva; A. H. Van Gennip; H. B. Kal πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 French βš– 850 KB

Time relationships of drug concentrations in tissue of a transplantable rat rhabdomyosarcoma and of tumour responses up to I20 hr after treatment with methotrexate (MTX) were analysed and compared. MTX was shown to be retained within the tumour in a substantial concentration for several days, althou