Pharmacokinetics and biological response
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J. B. A. Kipp; A. Leyva; A. H. Van Gennip; H. B. Kal
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Article
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1993
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John Wiley and Sons
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French
β 850 KB
Time relationships of drug concentrations in tissue of a transplantable rat rhabdomyosarcoma and of tumour responses up to I20 hr after treatment with methotrexate (MTX) were analysed and compared. MTX was shown to be retained within the tumour in a substantial concentration for several days, althou