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Impact of Treatment Acceleration and its Timing on the Response of the Rhabdomyosarcoma R1H of the Rat to Fractionated Irradiation

✍ Scribed by Annette Raabe; Sylvai Quaester; Hans-Hermann Dubben; Jörg O. Zieron; Andreas Krüll; Winfried Alberti; Hans-Peter Beck-Bornholdt


Publisher
Springer
Year
2001
Tongue
German
Weight
101 KB
Volume
177
Category
Article
ISSN
0179-7158

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Time relationships of drug concentrations in tissue of a transplantable rat rhabdomyosarcoma and of tumour responses up to I20 hr after treatment with methotrexate (MTX) were analysed and compared. MTX was shown to be retained within the tumour in a substantial concentration for several days, althou